Wharton’s Jelly Stem Cells: safety & more

ADVANTAGES OF WHARTON’S JELLY STEM CELLS ESPECIALLY MESENCYMALS (Designated as WJ-MSC for convenience below) ESPECIALLY WITH RESPECT TO SAFETY

WJ HAS MORE STEM CELLS THAN EITHER BONE MARROW OR ADIPOSE TISSUE

The quantity of mesenchymal stem cells which can typically be obtained from bone marrow is far less than that Wharton’s Jelly: 0.001 to 0.01% mononuclear cells from BM, with 1 g of adipose tissue yielding ~ 5 × 10³ stem cells, and Wharton’s jelly 1 to 5 × 10⁴ cells/cm of umbilical cord. In side-by-side comparison studies of MSC from bone marrow adipose tissue and Wharton’s jelly, WJ-MSCs had the highest proliferative capacity.

WJ STEM CELLS ARE MORE PRIMITIVE THAN OTHER ADULT STEM CELL TYPES YET DO NOT PRODUCE TUMORS AND ACTUALLY HAVE ANTI-TUMOR EFFECTS IN VITRO (Lab dish) AND IN VIVO (In living animals & humans)  

WJ-MSC differ from other adult MSCs with respect to the fact they demonstrate far more primitive characteristics e.g., they express embryonic-like stem cell markers including  pluripotency genes, Oct-4, Nanog, and SOX-2 but at levels well below that of embryonic stem (ESC) cells. Despite this, WJ-MSCs do not form tumors (teratomas). This is attributed to the fact that WJ-MS’s have a lower expression of pluripotency genes than embryonic stem cells (ESCs being very pluripotent and by virtue of this are prone to develop teratomas when injected into animals or humans). When WJ-MSCs were injected in immunocompromised and immunodeficient animals they still failed to form tumors.

Also: WJ-MSCs express low levels of the embryonic stem cell pluripotency markers POUF1, NANOG, SOX2 and LIN28, which also plays a role in the fact they do not produce teratomas. WJ-MSCs also synthesize and express several cytokines including IL12A which is associated with the induction of apoptosis (programmed cell death) which is believed to underlie their ability to lyse (eradicate) tumor cells.

Furthermore, the transcriptome of WJ-MSC and ESC differs substantially in that WJ-MSCs demonstrate high expression levels of several tumor suppressor genes and suppresses tumors both in vitro and in vivo. Moreover, large quantities of tumor growth inhibiting cytokines and growth factors are secreted by WJ-MSCs. Also, WJ-MSC cell lysates as well as the conditioned medium they are cultured in strongly inhibited the growth of breast adenocarcinoma, ovarian carcinoma, osteosarcoma, benign neoplastic keloid cells, bladder tumor, and lymphoma cells  in vitro. When WJ-MSC cell lysates and conditioned medium were injected into mammary carcinoma, osteosarcoma, and pancreatic and lung tumors it inhibited their growth and shrank the tumors in vivo .

WJ-MSCs DO NOT CAUSE IMMUNE REJECTION OR ADVERSE REACTIONS  

WJ-MSCs have also been found to be immunoprivileged which is to say they escape rejection or adverse immune reactions. Part of the reason for this lies in the fact WJ-MSCs have low MHC-I levels and an absence of MHC-II expression. And, though they synthesize low amounts of MHC class I, WJ-MSCs have no immunogenicity. Research indicates that this is due to the fact they  do not express costimulatory molecules such as CD 40, CD80, CD86, and also produce high levels of immune response inhibitors such as indoleamine-2,3-dioxygenase (IDO), prostaglandin E2 (PGE2) and leukocyte antigen G6 (HLA-G6).

NOVA CELLS INSTITUTE HARVESTS & MAKES CLINICAL USE OF STEM CELLS ISOLATED FROM (UMBILICAL CORD) WHARTON’S JELLY CELLS: https://ncimx.wordpress.com/2015/03/15/whartons-jelly-stem-cells/

ADDITIONAL REFERENCES – NIH PubMed results (5-1-2016)

	Wharton’s Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-β deposition in an APP/PS1 transgenic mouse model.
	Xie ZH, Liu Z, Zhang XR, Yang H, Wei LF, Wang Y, Xu SL, Sun L, Lai C, Bi JZ, Wang XY.
	Clin Exp Med. 2016 Feb;16(1):89-98. doi: 10.1007/s10238-015-0375-0. Epub 2015 Jul 19.
	PMID: 26188488 [PubMed – in process]
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	Therapeutic influence of intraperitoneal injection of Wharton’s jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis.
	Luo HJ, Xiao XM, Zhou J, Wei W.
	Genet Mol Res. 2015 Apr 17;14(2):3606-17. doi: 10.4238/2015.April.17.10.
	PMID: 25966129 [PubMed – indexed for MEDLINE] Free Article
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	Effect of human Wharton’s jelly mesenchymal stem cell secretome on proliferation, apoptosis and drug resistance of lung cancer cells.
	Hendijani F, Javanmard ShH, Rafiee L, Sadeghi-Aliabadi H.
	Res Pharm Sci. 2015 Mar-Apr;10(2):134-42.
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	Preserved β-cell function in type 1 diabetes by mesenchymal stromal cells.
	Carlsson PO, Schwarcz E, Korsgren O, Le Blanc K.
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Improvements coming out of the gate for Evie Morgan (3 year old little girl with Spina bifida)

Three year old Evie Morgan has spina bifida and a Facebook page devoted to her journey to betterment at https://www.facebook.com/evieswarriors/. She was treated in Mexico by Nova Cells Institute doctors during April (2016) and soon her Mum, Heather, was emailing NCIM a series of positive reports and video clips.  Heather also made posts to the aforementioned Facebook page — three of which follow further down below.

Evie in Mexico getting IV infusion

On 4-27-16 Heather Morgan sent this email message to NCIM:

We felt very comfortable in the hospital. The room was very clean and had a private bathroom and sink. The pediatrician, Dr. Sanchez, was amazing and Evie loved her so much. Dr. Sanchez spoke great English and we had no trouble understanding her at all. The nurses were very attentive to whatever it was that Evie needed and Grace was always right there to translate for us if they had questions or we wanted to say something. The procedure was quick and painless. Within 5 minutes of receiving the treatment Evie began moving her toes. In the week and a half since treatment Evie is still able to move her toes on command (prior to treatment Evie only had very little involuntary movement of her toes), she is urinating more on her own and has very increased balance. She is now beginning to walk much longer distances with her canes (before she had a walker). At her next urology appointment we are going to be able to start discussing next steps in seeing how her bladder can fully function without medication. We are very pleased with the results we have seen thus far and can’t wait to see what else Evie is going to do!

 Evie’s Warriors – Posted on April 22, 2016 (Friday)

 

This video was taken 2 days after stem cells. Evie is now able to move her toes on command! Before it was completely involuntary movement. Pardon her sassiness at the beginning 😂 Evie also has incredibly improved balance and is able to walk much longer distances with her canes! ‪#‎evieswarriors‬

Go to Evie’s Warriors Facebook page to watch

 

Evie’s Warriors

April 16 at 5:46pm ·

Evie is showing improvements in her bladder function and abilities since yesterday. We aren’t sure if this is going to be a consistent thing but we are definitely watching now. This is nuts.

Evie’s Warriors

April 15 at 5:49pm ·

Sorry for lack of updates. Everything went perfectly and the treatment is now complete. Within minutes Evie was flexing her right ankle when asked and wiggling all 5 toes. Some of the movement is involuntary right now as the cells are being repaired. We will continue to see results for a few months. Thank you all for supporting our girl! ‪#‎evieswarriors‬

Stem cell homing = Better clinical outcomes

Stem cell homing makes a big difference in clinical outcomes. Watch this short video to learn more about how Nova Cells pulls this off.  

Nova Cells Institute gets stem cells to target tissues using its Beacon Factor. Learn more by getting our FREE e-book “Heroic Medicine” (Click to download). Read about our successful stem cell treatments for spina bifida, cancer, stroke, dementia, autoimmune diseases, and more. Get your FREE e-book “Heroic Medicine” now!

Arthritis & vertigo turnaround in 85 year old lady from Nevada (USA)

In later 2014 eight-five (85) year old Patricia Rodriguez went to Mexico to have her longstanding arthritis treated by Nova Cells Institute. During her one day stay she was given umbilical cord stem cells that had been primed to become cells that fight arthritis and promote healing and joint restoration, along with the Beacon Factor.

Upon her return stateside, the very next day Patricia noticed a surge of energy and strength upon walking. However, week after week   positive things of all kinds began surfacing. Her  daughter, Tina, summarized these for Nova Cells as follows:

She has incredible strength in comparison to what was true before (her treatment). She can walk all over Walmart and then when we went to a mall near her home she walked the entire length of it not once but twice, and was only a little tired when we got back to her house”, although, I was tired too.

Tina added, “She can get up from the rocking chair without my daughter having to pull her up.  And she can open a can of soda using a finger that could not bear doing this last year”. This was one month after her treatment.

“Also, …and this is the latest thing,…for 48 years Mom had incredibly bad vertigo if she laid on her right side which did not happen when she laid down on her left side. She often said her vertigo was like having the room spin at one hundred miles per hour. Naturally when she slept she made every effort to sleep on her right side. Then last week she woke up on her right side and was absolutely shocked to find she had no vertigo. It has not returned!”

Four months after her treatment she had no arthritis pain, in her hands and right arm, whatsoever.

“Mom was also always afraid of losing her balance. She never fell, but she felt that she might one day do so. She would instinctively grab the rail to go up the stairs in her home and also in mine, and then slowly, cautiously take one step at  a time. She would hold onto the rail and moving up it by taking one step and at the same time moving her left hand over the right hand. She never would let one hand go until she had the other on the rail.”

“Now 5 months after her stem cell treatment she goes up the 15 stair staircase without holding onto anything.”

Nova Cells Institute Mexico offers free case evaluations: 

Call 1-562-916-3410

Email NCInfodesk@gmail.com

Many “giant steps” for Dani

Danielle “Dani” Smith was born in September 2006 with spina bifida in which her spinal cord did not completely form and resulted in partial paralysis from the waist down (Myelomeningocele). Since then this brave little girl has had five major operations including one to place her spinal cord back in her body, three brain surgeries, and double eye surgery. She then did two stem cell treatments and has undergone lots of physical therapy. And, during June 2013 she was treated in Mexico by Nova Cells using primed stem cells and its Beacon Factor. This treatment and Dani’s responses are reflected in this news release from October 2013: http://www.24-7pressrelease.com/pdf/2013/10/05/press_release_364003.pdf

Dani has made many gains during the year since that news release was published including, most recently, something captured by her mother in a short video. This clip was inserted in an animated video which can be accessed by going to https://www.youtube.com/watch?v=RUBvyFt0Vm4#t=109 or click the screen image below,

 

 

Facebook video & written update by Kara Underwood on her son, Bryson

Kara Underwood

Walking on the treadmill for the first time in his life! He’s in a harnessing system and only has braces from the knees down! We were told he would NEVER in his lifetime do this! All I have to say to every doctor that said NO and he CAN’T and he NEVER WILL is this…….we serve an awesome mighty God who says my son WILL WALK! He promises healing to all who ask for it as we receive it for our son in the name of Jesus!

Hayden’s Journey: 2 months after his NCIM stem cell treatment (Patient blogsite)

http://haydentrigg.blogspot.com/2014/08/two-months-post-stem-cell-treatment.html?spref=fb

Ryan Weber (Anoxic Brain Injury): Improvements began surfacing right after his treatment!

To Grace & All The Nova Cells Family:

Sorry for not getting back to you sooner but it has been crazy busy. Mexico was great, nothing we imagined. The hospital where Ryan received his Stem Cell Treatment was so clean and I have been in many different hospitals here in the United States that was not as clean. We enjoyed the Mexican food as it was so flavorful. It made me sad to leave.

Ryan’s Stem Cell treatment was a great success! We noticed a huge difference in his muscle tone when they brought him back from the O.R. I cried when I first picked Ryan up because it was like holding a different kid. Ryan’s muscle tone is completely relaxed. Ryan has started back up with his outpatient physical therapy, warm water therapy and his massage appointments. His therapist were shocked at the difference in his muscle tone. Ryan has more control over his muscles.

Some of the things Ryan has done since his Stem Cell Treatment that he was not able to do before hand include:

HEAD CONTROL -He holds his head in a neutral position now and freely moves it to the left and right to look around. Before Stem Cells, Ryan would either have it tilted to one side or the other or front or back.

Picture taken the day after Ryan’s treatment at the San Diego Zoo. Look at how his arms are more bend, his legs are bend, head in right position. Ryan is actually sitting on the tusk.

HANDS – Ryan is able to open and close his hands freely. He regained the infant grasp reflex. With this he is able to reach out and grab items. Last night (8/26/14), he reached up and grabbed his Dad’s glasses and the later in the night he reached up and grabbed a handful of my hair. Before Stem Cells, Ryan kept his hands closed in a tight fist.

Picture of Ryan’s hands after his Stem Cell treatment

ARMS – Ryan actually is able to control both his arms equally. He is able to bend both elbows at his choice. Ryan is able to control his arms to reach to get items he wants. He still favors the left arm over the right but he was left handed dominant. Before Stem Cells, Ryan did have minimal control over the left arm and no control over the right arm.

Rick and Ryan at the beach before Ryan’s Stem cell treatment. Look at the stiff straight arms and tight closed fist hands

TRUNK (TORSO) – Ryan is able to sit in upright position on our lap with little help. When Ryan sits his chest and belly are straighter. Before Stem Cells, Ryan sat on our lap and needed a lot of help to stay in upright position and usually was tilted to one side or the other.

LEGS – Ryan legs are able to bend at the knees. He is able to control them better alternating them to walk in his walker and today walked in the pool with very little help by himself without a walker. When Ryan sits on our laps Ryan will bend his knees and sit like any other “scientifically Normal” child. When he lays on the floor he will pick up his legs to reposition them. Before Stem Cells, Ryan legs were mainly in a locked straight position. It was a battle to have him sit on our lap, put him in his car seat or in anything that required him to be in a bend position. He would walk in his walker but his body looked like an “S”.

MENTAL – Ryan is happier; he smiles and laughs more. I credit the Stem Cells as he is not always having to deal with very tight muscle which were probably really sore. When Ryan looks at you, he just smiles like he can actually see us clearly. Before he recognized the important people like his siblings, Grandparents and us as his parents but since his Stem Cell treatment-couple of our friends have talked to Ryan and this time Ryan interacted with them.

Most of Ryan’s improvements have been “small” but when you put all the small pieces together it makes for a huge improvement. It’s the little things that matter. I have to tell you a story about our day before we were picked up to go to Mexico.

We were all around and waiting for the phone call to tell us you were on your way. We were sitting outside at the patio set when I opened my pictures in my Phone to find the Creative Miracle Prayer I wanted to say before Ryan’s Stem Cell treatment. My phone usually opens to the last picture taken but that day when I opened my pictures, I started to cry because it automatically opened to a picture of Rick holding Ryan the day he was born back on 12/17/09 (See below). Rick asked what was wrong and I turned my phone to show him the picture that popped up and his jaw dropped. This is the picture that popped up.

I took that as a sign from above that Ryan would be born again. With all of Ryan’s improvements that is exactly what happened! We cannot thank you all enough for making this miracle happen for Ryan. I will send pictures in another email with little explanations of them. Just wanted to get this email of Ryan’s improvements to you. You may share this with everyone and if they want to follow Ryan his Facebook page is www.facebook.com/littlewarriorryan.

Thank you for giving us our little boy back! Lots of love.

Gina & Rick Weber

Tatyana Kushniryuk shares wonderful news about her son Rowan’s response to treatment (Spina Bifida)

My son Roman was born with Spina Bifida in 2010. He is a L4-L5 level which means he cannot void on his own and does not have bowel control. His legs were very weak and he could not walk independently until he was 2.5 years old. He was able to hold on to a walker and push it slowly but the big change came after stem cells. He received his first stem cell treatment in China, and in Mexico twice since then. The latest change was from Mexico.

We arrived to San Diego a few days before treatment and checked into our hotel downtown. The next few days we spent exploring the city and taking a trip to the San Diego SeaWorld courtesy of Warrior Families Beating Spina Bifida Foundation. Roman really enjoyed that trip because he got to see the sea lions and pet the little sharks. He was not as excited about Shamu as I was.

The next day we were escorted to Mexico across the border by NCIM staff. They were really great and picked us up in their car and drove us to the hospital. The staff greeted us as we registered in as patients, signed some papers and answered questions about his blood type etc. I can understand how some people may be cautious signing things and giving consent to doctors in a different country but since I knew NCIM people from our previous trip to Mexico, I was at ease.

The doctors and nurses were very accommodating and made sure we were comfortable with our room and the procedure. It was much faster than I remember it the first time. The anesthesiologist and doctors talked about how they would only put him to sleep for a very short time and not keep him under sedation when not necessary. They had performed the spinal taps many times and knew their jobs very well. I felt confident in their care and did not have second thoughts about the procedure. I only wish that Roman cooperated as well as I thought he would. He did not like the taste of versed (the relaxing serum before procedures) so we opted to take him without it to the procedure room. The hospital has the coolest stair case that has a slide like side so they can transport people in a wheelchair up and down the twisty ramps.

During the procedure,  I went to eat at a local place so that I would not be nervous and we hurried back because Roman was not going to be in the procedure very long. After we came back, Roman was not awake yet but was brought in soon after. He did great; there was no pain in his back or the IV. He was a bit freaked out thinking that the procedure was just beginning after looking at his IV. It took a while to convince him that we are all done.

After about half an hour, he began eating everything, and I mean everything he could get his hands on. The Jell-O, the rice, the juice, the fruit cup. We had asked for refills. He was feeling really great; He said “Is this Mexico? I like Mexico”…while he’s eating and watching Netflix on our laptop. (by the way, Wi-Fi works there and I would take a laptop with Netflix if you have it.)

We had a great experience and soon after we left back across the border to our hotel room. We stopped on the way while NCIM staff treated us to some local cuisine of ice cream, then sandwiches while walking around the outside mall.

Since the trip we have noticed Roman waking up in the middle of the night saying he feels his butt more and that he has to go pee. One day after about 1.5 months he had a wet diaper. He has never had a wet diaper in 6 years! Since then his recurrent infections suddenly stopped and he has been having more strength in his legs to run and walk without his AFO shoes. I am excited seeing these results they are truly worth it! The peeing is becoming more consistent and we are seeing good results in his muscle strength as well.

I encourage anyone that wants to give their kiddo a chance to improve their life to take a chance and make this trip happen.

Tatyana Kushniryuk

VIDEO UPDATE: Bryson Chailer walking without braces!

Kara Underwood posted this video of her son, Bryson, walking without braces to You Tube on Thursday, 7-24-2014: https://www.youtube.com/watch?v=yIr5DJygq6k&feature=youtu.be

Bryson Chailer has some a long way thanks to faith, therapy and, yes, stem cell medicine! 

If you are not acquainted with Bryson’s story here is a link to an earlier Nova Cells Institute blog entry that contains information, links, photos and more: http://ncimx.wordpress.com/2012/05/06/bryson-chailer-rapid-impressive-improvements-in-child-with-spina-bifida/

Photo of Bryson with his Mum, Kara Underwood, taken during December 2013