New study underscores how messed up “garbage processing” in neurons causes major problems

NEW STUDY UNDERSCORES HOW MESSED UP “GARBAGE DISPOSAL” PROCESSING IN NEURONS CREATES BIG PROBLEMS: Breaking the brain’s garbage disposal (AUTOPHAGY): Study shows even a small problem causes big effects: http://medicalxpress.com/news/2016-01-brain-garbage-disposal-small-problem.html (1-26-2016)

Messed up cellular “garbage disposal system” found to play a role in Alzheimer’s disease (And Nova Cell’s BEACON FACTOR coaxes lysosomes to do their job!)

Many neurodegenerative diseases involve a failure of lysosomes (the “garbage disposal” system within cells including neurons) to do their job properly. Now comes evidence that defective or compromised lysosomes may contribute to Alzheimer’s disease, something ably laid out in a 6-30-15 article on the Medical Express website at http://medicalxpress.com/news/2015-06-failure-cells-garbage-disposal-contribute.html. Here is a salient quote from this article:

Lysosomes, the “garbage disposal” systems of cells, are found in great abundance near the amyloid plaques in the brain that are a hallmark of Alzheimer’s disease. Scientists have long assumed that their presence was helpful—that they were degrading the toxic proteins that trigger amyloid plaque formation.

However, in Alzheimer’s patients, these lysosomes lack the ability to do their jobs properly, and instead of helping, the accumulation of lysosomes may even contribute to the disease, Yale University researchers report the week of June 29 in the Proceedings of the National Academy of Sciences.

The new findings raise the possibility that coaxing lysosomes to do their jobs could help to prevent the toxic processes that eventually destroy the minds of Alzheimer’s patients.

The big question is how to get lysosomes to do their job as they should. While medicine has little that can pull this off, Nova Cells possesses an effective, nontoxic way to do so: Namely its  proprietary Beacon Factor. Not surprisingly, many patients with neurologic diseases and conditions that involve fouled up lysosomes have responded quickly and beautifully to intravenous infusions of the Beacon Factor. Click to read some of the case histories.

http://www.pnas.org/content/early/2015/06/24/1510329112

Jane from the “Show Me” State of Missouri – Older lady with Parkinson’s disease & Lewy Body Dementia

Note by Nova Cell’s patient educator & care facilitator concerning Jane at the time she was picked up for transport to Mexico plus a brief summary of what took place after her Beacon Factor & stem cell treatments:

Jane arrived seated in a wheelchair with both hands and arms shaking, the left more so than the right. I knew from her history that she was no longer able to walk without assistance. Her son and her partner kind of lift and drag her from her wheelchair to other seating. She is incontinent and thus uses adult Pampers. Very thin ones. She came to treatment accompanied by her live-in partner and her son, both of whom are named Paul. She is given to having occasional hallucinations and is not aware of what is going on around her.

Jane was given large doses of the Beacon Factor by IV drip the first day in hospital. At night she asked to be helped to the restroom. Her partner and son helped her though she walked to the bathroom, and was not dragged.

The day after her stem cell infusion by both spinal tap and IV, Jane became more alert and began looking at her partner and son directly and was conversing with them. She didn’t say a whole lot but she was definitely more aware of everything and everyone around her. She even said “What is going on?”

Notes made by Jane’s son Paul and sent to NCIM:

Jan 20, 2016

1 pm PST, drove down from San Diego to TJ .

Checked into the hospital

3 pm PST: She ate some soup with lime Jell-O.

4 pm PST: The doctors put in an IV and began a saline drip. Mom took her usual medication.

5 pm PST: The doctor added the first dose of “The Beacon Factor”. We ordered dinner, tuna fish sandwiches, mixed fruit with bananas, mango and apples, some apple juice and water.

Mom seem to perk up while eating a lot, offering food to her partner and I while discussing how good she felt.

Tested her memory several times, which was still spotty, but she seemed concerned that she was “failing”.  Noticed that she had her eyes wide open and answered questions quickly, even though sometimes she didn’t make a lot of sense.  We both noticed she had more coherent thought processes and conversation.

7 pm PST: Mom took her final medication of the day.

Jan 21, 2016

6:30 am PST: Arrived back at the hospital. Mom was a bit frantic.

Really need an interpreter the whole time.

Changed bedding and dressings.

7:00 am PST: Mom was given her morning meds.

Took Mom to the restroom.

9:00 am PST: Mom seemed much more lucid, looking around.  Finally started to fall back to sleep after eating.

Changed bedding again and her dressings.

She slept until 11:30 am

1 pm PST: Anesthesiologist arrived and introduced himself and the fact he would be giving her a local in her back for the spinal puncture stem cell injection procedure.

2pm – 3pm PST: Talked with Mom who sat up on her own a lot, looked around a great deal, though she was still hallucinating and engaged in some nonsensical talk. Observed what was going on, and looked forward to going home.  During conversations she started in with “Come here doggie” and “There’s an old woman, really old, scary, staring at me”

Mom’s facial expressions became much more expressive. She was picking her lips and began folding her blankets and fidgeting a lot.

3 pm PST: The MD arrived to check her blood pressure, heart and blood oxygen level.

3:30 pm PST: Still waiting for them to take her in for her infusion.

She’s asking lots of questions and thinking very clearly after all the “Beacon Factor”.

4:00 pm PST: Mom left to go get stem cells.

5:20 pm PST: Mom was returned to the room, still very groggy from the anesthesia but doing well.

6:00 pm PST: Mom exhibited nearly normal behaviors (for her) of obsessing, and mumbling, but without leaning over as she usually did.  More eye movement and she was more concerned over recent events.

8:00 pm PST: Final dose of regular medicines for the day, after which she quickly became very groggy and tired.

9:00 pm PST: Returned to hotel room

Friday Jan 22, 2016

Returned home to Missouri after a day of travel.

Noticed several things, including obsessive behavior though not as extreme. Mom could be easily instructed to lean back, and she looked through the pages of magazines without tearing up the pages as she’d done in the past.  During changing, she lifted herself up as instructed.  Much more focus than before and she kept up conversations on current topics longer than had been true previously.